What lens abnormality is characteristic of Weill-Marchesani syndrome?

• A. Microspherophakia leading to lens subluxation and high myopia
• B. Ectopia lentis
• C. Anterior lenticonus
• D. Posterior subcapsular cataract

Answer: (D)

Weill-Marchesani syndrome is characterized by microspherophakia—the lens becomes small and highly spherical due to developmental abnormalities of the lens and its suspensory zonules. This shape increases the lens’s refractive power, leading to high myopia, and the lens can sublux or dislocate if zonular support is weak. So the lens abnormality that fits best is microspherophakia with potential lens subluxation and resulting high myopia. Other lens findings, like ectopia lentis from Marfan or homocystinuria, anterior lenticonus from Alport syndrome, or a posterior subcapsular cataract, are not typical features of this syndrome.